Monday, October 2, 2017

Girl on LSD

It is being reported that Tom Petty is in critical condition on life support after being found in cardiac arrest. Some outlets have reported he has passed. I have grown up listening to Petty's music - through high school and college and into adulthood. His music has been a huge part of my music listening life. So many good songs. So many good associations.

His most beautiful song? Wildflowers.

Best song to drive to? You Wreck Me and Runnin' Down A Dream. Preferably played back to back.

One of the first songs I knew all the words to? Free Fallin

Biggest song memory in junior high/high school? You Don't Know How It Feels

Song that makes me think about life? Learning to Fly

Coolest music video? Don't Come Around Here No More - I'm a sucker for Alice in Wonderland themes.

Song I can't help but sing no matter where I am? Mary Jane's Last Dance, always thought it was neat that it mentioned Indiana, then found out later it was originally titled Indiana Girl and thought that was even more awesome.


But the song I'll never forget is the one song that never made it to an album because it was deemed too controversial at the time by record execs, but was the B side on the 1994 single release of You Don't Know How It Feels...

Girl on LSD.



Such a great song from a drug and toxicology perspective.

Marijuana.
Cocaine.
Beer.
Crystal meth.
Glue.
Ecstasy.
Pills.
China White (aka heroin).
Caffeine.

Give it a listen. And while you're at it, smile and throw some good thoughts out there. The world needs some positivity these days.

Peace.

Update: Tom Petty has passed on. The Rock Band In The Sky added one more member.

Saturday, September 23, 2017

Toxicology of Designer Drugs (Lecture 3, Fentanyl, Fentanyl Analogs, and Designer Opioids)

The third installment of Toxicology of Designer Drugs focused on the emergence of fentanyl, fentanyl analogs, and other designer opioids in modern street heroin.

The outline of topics for this lecture included:

Fentanyl, Fentanyl Analogs, and Designer Opioids

    • Sliding scale of harm
      • Water
      • SSRI antidepressants
      • Benzodiazepines
      • Tricyclic antidepressants
      • Barbiturates
      • Opiates / Opioids
    • Opioid Deaths in the USA (Pre-2014/2015)
      • 2000 - 2014 data
      • Opioid analgesic deaths continue to rise
      • Surge in deaths, two trends
      • Double trouble: heroin and fentanyl
    • Heroin
      • History
      • Chemistry
      • Pharmacology
      • Metabolism
      • Forms of the product
      • NFLIS data, 2001 - 2016
    • Fentanyl
      • History
      • Chemistry
      • Pharmacology
      • Metabolism
      • Forms of the product (licit vs. illicit)
      • Death of Prince
      • NFLIS data, 2001 - 2015
      • NFLIS data, 2013 - 2015
      • NFLIS data, 2016
      • NY Times report on trends in US overdose deaths, 2017
    • Fentanyl Analogs
      • What are they? Where do they come from?
      • How many compounds exist?
      • DEA scheduling actions, 2015 - 2017
      • DEA Emerging Threats Reports, 2017
      • Overdoses, hospitalizations, and reported deaths in media
      • Analyte Specific Looks
        1. 3-methylfentanyl (cis/trans)
        2. Acetylfentanyl
        3. Furanylfentanyl
        4. Acrylfentanyl
        5. Carfentanil
    • Designer Opioids
      • Opioid research chemicals
        1. U47700
          • Death of Prince
        2. AH7921
        3. MT-45
    • Analytical Methods
      • Method development
      • Method validation
      • Organic extraction
      • Instrumental analysis via LC-MS/MS
    • Prevalence
      • What drugs have been detected?
      • How prevalent are they?
      • What locations are they found?
      • Special look at Carfentanil detections
    • Postmortem Case Studies
      • Case 1 (Information Withheld)
      • Case 2 (Information Withheld)
      • Case 3 (Information Withheld)
      • Case 4 (Information Withheld)
      • Case 5 (Information Withheld)
      • Case 6 (Information Withheld)
      • Case 7 (Information Withheld)
      • Case 8 (Information Withheld)
    • Testing for Fentanyl Analogs and Designer Opioids vs. A Fishing Expedition
    • Conclusions

Toxicology of Designer Drugs (Lecture 2, A Brief History of Designer Drugs)

Here is the next installment of my Toxicology of Designer Drugs class - this lecture focused on a high level look at the timeline of designer drugs in the USA.

A Brief History of Designer Drugs
    • 1960s and 1970s
      • LSD
      • Mescaline
      • DOM (STP)
      • PCP / TCP / PCE
    • 1980s
      • Fentanyl derivatives (China White)
      • MDMA
      • MPPP / MPTP
      • Methamphetamine / Methcathinone / 4-methylaminorex
    • 1990s
      • Anabolic steroids
      • Research chemicals
      • The 2C family and PiHKAL / TiHKAL
    • 2000s and 2010s
      • Cathinones and designer stimulants
      • Synthetic cannabinoids
      • Analogs of sildenafil / herbal supplements
      • Designer opioids / fentanyl analogs
      • Benzodiazepine derivatives
      • NBOMes
      • Methoxetamine
      • Nootropics

Toxicology of Designer Drugs (Lecture 1, Introduction to Forensic Toxicology)

I'm teaching a toxicology of designer drugs course at IUPUI this fall via the Forensic and Investigative Sciences Program.

The outline of topics for the first lecture included:

Introduction to Forensic Toxicology

    • The Realms of Forensic Toxicology
      • Human Performance
      • Postmortem
      • Drug Facilitated Crimes
      • Urine Drug Testing
    • The Role of the Forensic Toxicologist
      • Analyze specimens
      • Analytical instrumentation
      • Develop and validate testing methods
      • Case review and release
      • Results interpretation
      • Education
      • Expert and fact witness courtroom testimony
      • Research, publish, and present
    • Autopsy and Toxicology Specimens
      • Blood
      • Urine
      • Vitreous Humor
      • Tissues
      • Bile
      • Gastric contents
      • Alternative matrices
    • Toxicological Terms
      • Pharmacokinetics
        1. Dose
        2. Dosing interval
        3. CMax
        4. TMax
        5. CMin
        6. Volume of distribution
        7. Concentration
        8. Elimination half life
        9. Elimination rate constant
        10. Bioavailability
      • Pharmacodynamics
        1. Onset vs. Duration of action
        2. Receptor agonism
        3. Receptor antagonism
        4. Receptor inverse agonism
        5. Catecholamines / Neurotransmitters
          • Serotonin
          • Norepinephrine
          • Dopamine
          • Histamine
          • Acetylcholine
          • GABA

Forensic and Investigative Sciences (FIS) Program Seminar Series - 2017

I'm thrilled to be giving a talk today in the Indiana University-Purdue University Indianapolis (IUPUI) Forensic and Investigative Sciences (FIS) Program Seminar Series at 3:30 pm.

The title of the talk is:

"Not Your Father's Heroin: Forensic Toxicology in the Age of Fentanyl and Fentalogs"

While you're reading this, why not pop into IUPUI's FIS Program website and have a look around? They've got some really cool things happening.

Tuesday, September 19, 2017

Visited Purdue University Today

I visited Dr. Susie Swithers' Drugs and Behavior class at Purdue University today and introduced the students to forensic toxicology. Had some good interactions with the students. I have fun with things like this - love outreach and education.

While you're reading this, why not peruse Purdue's Psychological Sciences website and learn something new?

Forensic Toxicology Job Listings

Some good job opportunities are out there for forensic toxicology!

The following are good references and sites for job postings:

Society of Forensic Toxicologists - Job Listings

American Academy of Forensic Sciences - Job Postings

Midwestern Association of Forensic Scientists - Employment

Southwestern Association of Forensic Scientists - Employment

Northeastern Association of Forensic Scientists - Employment